The aim of the present work was to prepare caffeine niosomes by thin film hydration method using various types of surfactants and applying different surfactant: cholesterol ratios for the treatment of cellulite. Surfactant used were (span 20, 60, 65, 80 and 85), cholesterol was added with (0, 10, 20, 30, 40 and 50%). The prepared niosomes were evaluated by determination of particle size using transmission electron microscope (TEM), determination of entrapment efficiency (E.E. %) and in-vitro drug permeation study through rat skin. The particle size of the prepared niosomes ranged between 174 and 380 nm, the highest entrapment efficiency of caffeine (94.18%) occurred with span 60 (F12S60) which contains Span 60: Cholesterol with ratio (50:50) respectively. While (F22S80) which contains Span 80: Cholesterol with ratio (70:30) respectively gave the highest steady state flux of (62.51 µg cm-2 hr-1).The results revealed that Span 60 gave the highest entrapment efficiency and Span 80 gave the highest in-vitro permeation.
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